Wegener’s granulomatosis

• • Systemic disorder of unknown aetiology
  • Involves
    • Upper airways
    • Lungs
    • Kidneys
    • Skin

• Clear or blood-stained nasal discharge
  • later becomes purulent
• Patient complains of “persistent cold”
• crusting, granulations, septal perforation in nose
• General systemic symptoms
  • Anaemia
  • Fatigue
• Night sweats
• Migratory arthralgias
• Lung - cavitary lesions on xray
• Kidney involvement
  • Elevated serum creatinine
  • Urine
    • Presence of red cells
    • Cast and albumin

• Biopsy from the nose is diagnostic
  • Shows necrosis, ulceration of mucosa
• ESR is raised ​​​​​​​

• • Systemic steroids
  • Cytotoxic drugs
    • Cyclophosphamide
  • Immunosuppresasnts
    • Azathiorpine

6th edition : Diseases of ENT & HN surgery

PL Dhingra, Shruti Dhingra

Page No. 159-160